BIOMEDICAL IMPORTANCE OF DNA:
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| Biomedical Importance Of DNA |
Mutations are due to a change in the base sequence faulty sequence of DNA. They may result from the faulty replication, movement, or repair of DNA and occur with a frequency of about one in every 10⁶ cell divisions. An abnormal gene product can be the result of mutations that occur in coding or regulatory-region DNA. A mutation in a germ cell will be transmitted to offspring (so-called vertical transmission of hereditary disease).
Factors Effecting DNA Sequence:
A number of factors, including viruses, chemicals, uliraviolet light, and ionizing radiation, increase the rale of mutation. Mutations of- ten alfect sOmatic cells and so are passed on to suc cessive generations of cells within an organism. It is becoming apparent that a number of diseases, and perhaps most cancers, are due to this horizontal transmission of induced mutations.
_upon_exposure_to_IR_determines_the_biological_outcome_in_cellular_and_organismal_contexts.png "A dynamic interplay between the amount of DNA damage and DNA damage response (DDR) upon exposure to IR determines the biological outcome in cellular and organismal contexts.")
